Two veteran protein engineers team up to create a new gene-delivery vehicle.
Adenoviruses as gene-delivery vectors took a hit 20 years ago, with the tragic death of a young man who was being treated for ornithine transcarbamylase deficiency using an adenovirus-delivered gene therapy. Since then, adeno-associated viruses and lentiviruses have been the mainstay gene deliverers. With their 2022 start-up Vector Biopharma, Andreas Plückthun of the University of Zurich and serial pharmaceutical executive Lorenz Mayr aim to bring adenoviruses back.
Manufacturing also presents a challenge, as a virus devoid of any genetic material requires a helper virus for replication, which then must be disposed of. Schaffer says the production of helper-dependent adenovirus can be difficult to scale. To address this, Vector is looking to lower the dose required to get a therapeutic effect by improving the efficiency, for example through trimerizing the adaptors.
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