Long-term use of proton pump inhibitors, a type of acid reflux medication, may be linked to an increased risk of dementia, suggests a study recently published in Neurology, the medical journal of the American Academy of Neurology. Importantly, this research doesn't establish that these drugs directl
has found that people taking proton pump inhibitors for more than 4.4 years may have a 33% higher risk of developing dementia compared to non-users.reflux medication, may be linked to an increased risk of dementia, suggests a study recently published in. Importantly, this research doesn’t establish that these drugs directly cause dementia but only indicates a correlation.
Proton pump inhibitors reduce stomach acid by targeting the enzymes in the stomach lining that produce that acid. Researchers determined if participants took acid reflux drugs by reviewing their medications during study visits and during yearly phone calls. Of the participants, 1,490 people, or 26%, had taken the drugs. Participants were then divided into four groups based on whether they had taken the drugs and for how long, as follows: people who did not take the drugs; those who took the drugs for up to 2.8 years; those who took them for 2.8 to 4.4 years; and people who took them for more than 4.4 years.
After adjusting for factors such as age, sex, and race, as well as health-related factors such as high blood pressure and diabetes, researchers found people who had been taking acid reflux drugs for more than 4.4 years had a 33% higher risk of developing dementia than people who never took the drugs.
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