The study comes as Novo Nordisk’s Wegovy, Ozempic and similar treatments skyrocket in popularity in the U.S. for causing dramatic weight loss over time.
Blockbuster weight loss and diabetes drugs like Wegovy and Ozempic may be associated with an increased risk of three rare, but severe, stomach conditions in non-diabetic patients, according to a new study released Thursday.
GLP-1s work by slowing digestion to suppress a person's appetite but can cause problems if that process slows down too much., which slows or completely stops the movement of food from the stomach to the intestine and can cause symptoms like persistent vomiting. "That's why we kind of wanted to take diabetes out of the equation," said Mohit Sodhi, one of the authors of the study."In addition to the fact that millions of people around the world are using these drugs to help them lose weight."The study findings are based on an analysis of health insurance claim records for roughly 16 million U.S. patients.
"Our data end date was the end of 2020, while the recent boom in semaglutide happened in the last year," Sodhi said."Nonetheless, we believe it is a class effect." Around 7 out of every 1,000 patients experienced stomach paralysis while taking liraglutide, and nearly 10 out of every 1,000 patients experienced that condition while taking semaglutide."When you have more than a million people taking the medication worldwide, that's 10,000 people who could potentially experience gastroparesis according to the incidence rate for semaglutide," he told CNBC."It's rare, but that's still a lot of people.
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