This article discusses what a neurofilament light (NfL) intermediate filament protein is and how it can be measured.
Sponsored Content by QuanterixJun 4 2024Reviewed by Olivia Frost Neurofilament light is a 68 kDa cytoskeletal intermediate filament protein highly expressed in neuronal axons. It is associated with the 125 kDa Neurofilament medium and the 200 kDa Neurofilament heavy to form neurofilaments.
CSF and blood NfL can increase in patients with Alzheimer’s Disease , Multiple Sclerosis , Parkinson’s Disease , Amyotrophic Lateral Sclerosis , Huntington’s Disease stroke, traumatic brain injury , and other neurological conditions. This positions NfL as a promising biomarker. What is the Simoa® difference? Simoa® is a valuable digital immunoassay technology that provides up to x1000 greater sensitivity than standard sandwich-based immunoassay methods. Traditional ELISA measurements are restricted to pg/ml levels of identification. Quanterix Simoa® can obtain sensitivity measurements at the lower femtogram levels.
Quanterix offers Simoa® NfL testing as a lab-developed test per CLIA and CLSI guidelines. Quanterix’s state-of-the-art facility has a CLIA-licensed lab that supports over 400 global customers. Using sizeable normative reference range databases, the Simoa NfL-LDT has been chosen for clinical use in numerous applications.
A conclusive diagnosis by a clinician can only be formed once symptoms start to present. This means that many patients wait years for a diagnosis or clear treatment plan.
Nfl Intermediate Filament Protein Filament Protein
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