What to know about prescription drugs promising weight loss

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What to know about prescription drugs promising weight loss
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WeightWatchers' acquisition of a telehealth company is the latest commercial push into the market for a new generation of medications that are promising significant weight loss.

Supply problems and soaring demand last year led to a shortage of the drugs, but Novo Nordisk, the manufacturer, said those have been replenished.They mimic the action of a gut hormone that kicks in after people eat, boosting the release of insulin, blocking sugar production in the liver and suppressing appetite.

A newer drug, called tirzepatide, mimics the action of two hormones for even greater effect. The Eli Lilly and Co. drug, sold under the brand name Mounjaro, is now approved to treat diabetes, but theWith lower appetite and a greater feeling of fullness, people using these drugs eat less and lose weight.

This image shows the logo of WeightWatchers on a mobile phone, and the company's website, in New York, on March 7, 2023.In a clinical trial, adults who took Wegovy saw a mean weight loss of nearly 35 pounds, or about 15% of their initial body weight. Adolescents lost about 16% of their body weight. A clinical trial of Mounjaro, which is still being studied, saw mean weight loss of 15% to 21% of body weight depending on the dose,In a typical weight-loss program where participants rely only on diet and exercise, about a third of people enrolled will lose 5% or more of their body weight, noted Dr. Louis Aronne, director of theMost people find it difficult to lose weight because of the body’s biological reactions to eating less, he said.

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