Wholebloodexchange could offer disease-modifying therapy for Alzheimer'sdisease, study finds UTHealth MolPsychiatry
A research team led by senior author Claudio Soto, Ph.D., professor in the Department of Neurology with McGovern Medical School at UTHealth Houston, in collaboration with first author Akihiko Urayama, Ph.D., associate professor in the department, performed a series of whole blood exchange treatments to partially replace blood from mice exhibiting Alzheimer's disease-causing amyloid precursor proteins with complete blood from healthy mice of the same genetic background.
However, the treatment of Alzheimer's disease has long been complicated, due to the difficulty in delivering therapeutic agents across the blood-brain barrier. Through their latest research, Urayama, Soto, and others discovered that manipulating circulating components in Alzheimer's disease could be the key to solving this issue.
After multiple blood transfusions, the researchers found that the development of cerebral amyloid plaques in a transgenic mice model of Alzheimer's disease was reduced by 40% to 80%. This reduction also resulted in improved spatial memory performance in aged mice with the amyloid pathology, and lowered the rates of plaque growth over time.
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