Researchers determined that valproic acid prevents nervous system cells from properly developing and dividing When used during pregnancy, the drug valproic acid, which is used to treat bipolar disorder, migraines, and epilepsy, can lead to birth defects. Now, research recently released in the journ
Researchers discovered how valproic acid, a medication commonly used to treat epilepsy, migraines, and bipolar disorder, causes birth defects when taken during pregnancy.
VPA is frequently used to treat a variety of diseases. However, since its first use, there have been many instances of pregnant women using VPA giving birth to kids who had birth abnormalities such spina bifida, facial changes, and heart malformations. A third of exposed newborns also develop cognitive decline and Autism Spectrum Disorder.
Keyes and colleagues examined embryonic exposure to VPA in the new study by using both human organoids—three-dimensional collections of human cells generated in the lab—and mice. They found that neuroepithelial cells, which are the stem cells that give rise to the central nervous system, undergo cellular senescence as a result of VPA. The researchers also identified p19as the specific molecule that caused this VPA-induced senescence.
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