There is no single treatment for depression that will work for all patients. Here's why—and what it could mean for the future.
and genetic vulnerabilities. For others, there are no external “reasons” for MDD; it seems to be something innate within them. Consequently, this latter subtype of depression was once called"endogenous depression" or"melancholia.
What if they were right? What if these “chemical imbalances” are only occurring in a small subset of patients with depression, but being prescribed to all patients, thereby explaining the confusing data? What if the far more frequent cause of depression is linked not to neurotransmitter dysfunction, but neuroinflammation?Inflammation occurs when the body’s immune system responds to injury or infection. If you scrape your arm, it will hurt, turn red, and maybe even be warm to the touch.
Ordinarily, inflammation is not problematic. In fact, it is an absolutely necessary process because it prevents further damage to cells by clearing infections, irritants, and any dead or damaged cells. Once cleared, the inflammation dissipates, and things return to normal.
, limited sleep, a lack of exercise, and exposure to pollution. The result is chronic systemic inflammation, which produces pro-oxidant proteins, which causes more oxidative stress, which causes more inflammation.
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