Although the development of Parkinson’s disease has been closely linked to variants of at least 20 different genes, scientists are still investigating exactly how they cause the severe and incurable motor disorder that afflicts around 1 million people in the U.S. alone. Yale researchers have just
New research by Yale researchers offers important clues into the genetic causes of Parkinson’s disease, a severe and incurable motor disorder.
Yale researchers have just completed new studies that offer important clues. In two new research papers, scientists provide insight into the function of a protein called VPS13C, one of the molecular suspects underlying Parkinson’s, a disease marked by uncontrollable movements including tremors, stiffness, and loss of balance.
They reported in 2018 that VPS13C forms a bridge between two subcellular organelles — the endoplasmic reticulum and the lysosome. The endoplasmic reticulum is the organelle that regulates the synthesis of most phospholipids, fatty molecules that are essential for building cell membranes. The lysosome acts as the cell’s digestive system. They also showed that VPS13C can transport lipids, suggesting that it may form a conduit for the traffic of lipid between these two organelles.
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