Our brain is actively surveying the fat.
is actively surveying your fat, rather than just passively receiving messages about it," says co-senior author Li Ye, Ph.D., the Abide-Vividion Chair in Chemistry and Chemical Biology and an associate professor of neuroscience at Scripps Research."This is yet another example of how importantare to health and disease in the human body," says co-senior author and professor Ardem Patapoutian, Ph.D., who is also a Nobel laureate and a Howard Hughes Medical Institute investigator.
Before the recent study, the scientific world thought that adipose tissues were linked via the sympathetic nervous system. The research team had to create completely new imaging modalities to get the results of this research.Ye and his colleagues decided to use two novel methods to elucidate the study.
Firstly, the team used an imaging technique called HYBRiD to make mouse tissues transparent, allowing them to better track the paths of neurons as they snaked into adipose tissue. The researchers discovered that nearly half of these neurons did not connect to the sympathetic nervous system but rather to the dorsal root ganglia, which is where all sensoryThe team then used a second technique, which they called ROOT, for "retrograde vector optimized for organ tracing" to more thoroughly investigate the function of these neurons in adipose tissue.
"The discovery of these neurons suggests for the first time that your brain is actively surveying your fat, rather than just passively receiving messages about it," said co-senior author Li Ye. "The implications of this finding are profound."Adipose tissues communicate with the central nervous system to maintain whole-body energy homeostasis.
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