A Diabetes Drug Could Protect Against Alzheimer’s Disease, New Research Suggests
Fortunately, this new study’s findings may have realized a new promising candidate for the treatment of Alzheimer’s.
Dr. Milstein adds that “the study found that the genetic variants in the sulfonylurea genes were linked to a lower risk of Alzheimer's disease. Thus, these genes are a potential target for the treatment of Alzheimer's.” Specifically, the researchers found that genetic variation in sulfonylurea targets was associated with higher insulin secretion, a lower risk of type 2 diabetes, and a lower risk of Alzheimer’s .
Although this groundbreaking study has great strengths, it also has many important limitations to consider. For one, given that genetic effects are lifelong, the study’s estimates cannot reflect the effects of exposure to sulfonylureas during a certain period of life. Also, some diabetes medications, including metformin, were excluded from the analysis because of unknown gene targets and effects.
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