Researchers at the Icahn School of Medicine at Mount Sinai have been awarded a $10.2 million grant from the National Heart, Lung and Blood Institute of the National Institutes of Health to investigate risk factors for malignant arrhythmias in mitral valve prolapse.
Reviewed by Danielle Ellis, B.Sc.Sep 26 2023 This work aims to develop a better understanding of the condition and novel solutions to improve patient outcomes.
In the United States, it is estimated that between 7 and 9 million people have mitral valve prolapse, the most common form of valve disease. The mitral valve is one of four valves in the heart that keep blood flowing in the right direction. Mitral valve prolapse occurs when two flaps within the mitral valve don't close smoothly or evenly, but instead bulge upward into the left atrium when the heart contracts.
Recent landmark work from the team used novel positron emission tomography and magnetic resonance imaging to identify inflammation in the heart in conjunction with identifying fibrosis. "Since the initial descriptions of mitral valve prolapse syndrome, a linkage to the risk of sudden death was identified. Our recent work, along with that of others, is starting to unravel the connection between mitral regurgitation and cellular changes in the ventricle which can be compensatory, but also create the substrate for ventricular arrhythmias," says Dr. Adams.
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