A new weapon against COVID: RBD-62 protein shows promising results in preventing severe disease biorxivpreprint covid COVID SARSCoV2 disease immunology disease severity
By Dr. Chinta SidharthanJun 15 2023Reviewed by Lily Ramsey, LLM In a recent study posted to the bioRxiv* preprint server, researchers used aerosolized receptor binding domain -62 with 1,000-fold enhanced binding affinity for angiotensin converting enzyme-2 to treat rhesus macaque models challenged with the Delta variant of severe acute respiratory syndrome coronavirus 2 .
However, the emergence of the Omicron variant and its sub-variants has challenged the immunity induced by primary and booster vaccine doses and previous SARS-CoV-2 infections. About the study In the present study, the researchers tested the efficacy of a mutated SARS-CoV-2 RBD developed in vitro, which binds to the ACE-2 receptor with high affinity without inhibiting the enzymatic activity of ACE-2.
The present study used rhesus macaque models and tested the efficacy of RBD-62 in protecting against infection with the Delta variant, which is believed to be the most pathogenic of all the SARS-CoV-2 variants to the macaques. The mucosal and serum levels of immunoglobulin g binding titers against various RBDs, including those from the wild type, Delta, and Omicron BA.1 variant, were also evaluated to determine the impact of the treatment on the development of primary or secondary immune responses.
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