Apathy in MCI may herald conversion to Alzheimer's. medtwitter Alzheimers
Approximately 80% of patients with MCI go on to develop AD within a 6-year period, the investigators note."Given the impact of AD, it is paramount to define parameters associated with distinct trajectories of MCI patients, especially identifying those who are more prone to develop AD."Neuropsychiatric symptoms are reported in an estimated 35% to 85% of patients with MCI and also are often present in the early stages of AD, preceding the onset of measurable cognitive decline.
TARCC is a state-funded longitudinal multisite study consisting of a cohort of adults ≥ 50 years old who are noncognitively impaired, patients with MCI, and patients with AD. The study included 1092 individuals diagnosed with MCI at any time point during the study . The cohort was evenly divided between Hispanic and non-Hispanic participants.Researchers performed a total of 2897 observations, with the number of observations ranging from 1 to 9 per individual and a median observation count per participant of 2 .During the study period, 17.3% of participants experienced conversion from MCI to AD across all observations, with a median time-to-conversion of 6.4 years.
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