Butylphthalide, a new medication that comes from celery seed, could improve outcomes after a clot-caused stroke when given in addition to prompt treatment for the clot, according to a new study.
Patients who received the treatment had less severe brain symptoms and better daily functioning 90 days after the stroke, as compared with those who received clot treatment and a placebo medication.
“Patients who received butylphthalide had less severe neurological symptoms and a better living status at 90 days post-stroke, compared to those who received the placebo,” Jia says. “If the results are confirmed in other trials, this may lead to more options to treat strokes caused by clots.”In China, previous studies in animals have found that butylphthalide has the potential to protect the brain from damage related to a stroke caused by a clot in the brain. Testing in humans has now begun.
The research team defined the outcomes as “favorable” if a patient fell into one of these categories at 90 days after the stroke: an initially mild to moderate stroke and no symptoms after treatment; an initially moderate to serious stroke and no symptoms or mild symptoms that didn’t stop them from doing daily activities after treatment; or an initially serious to severe stroke and no symptoms or a slight disability that impaired some activities after treatment.
Butylphthalide also improved function among all the patients, including those who initially received tPA, those who received mechanical clot removal, and those who received both. “While these are interesting results, this is only one relatively small study on a fairly select population in China,” says Daniel Lackland, DrPH, a professor of neurology and director of the Division of Translational Neurosciences and Population Studies at the Medical University of South Carolina.
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