Diet, body clock, hormones, and metabolism: What's the link? AskADoctor DailyHealthTips HealthcareMagic
Glucocorticoid drugs and a condition called Cushing syndrome, both of which raise glucocorticoid levels, can have the same effect.The new study aimed to understand the connection between the daily stress hormone surges, the biological clock, and metabolic cycles by focusing on glucocorticoid receptors.
For the new study, the team investigated the metabolic activity of glucocorticoids in the livers of mice by assessing the properties of their matching receptor. The methods that they used allowed them to show that the effects of glucocorticoids were different when the animals fasted during sleep, and while they fed when they were awake and active.The researchers found that the glucocorticoid receptor exerted these effects through time-sensitive binding with the genomes of the liver cells.
The researchers showed that the livers of mice that lacked the receptor did not control fat and sugar levels according to day and night.
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