Does vitamin D play an anti-viral role against SARS-CoV-2? MDPIpharma SARSCoV2 covid coronavirus COVID19 virus vitamin vitaminD
By Dr. Chinta SidharthanMar 17 2023Reviewed by Danielle Ellis, B.Sc. In a recent study in Pharmaceutics, researchers screened various compounds for anti-viral properties against severe acute respiratory syndrome coronavirus 2 . Additionally, in vivo and cell-based studies were adopted to investigate further the anti-viral properties of the active form of vitamin D, calcitriol.
About the study The present study used human nasal epithelial cells, Vero E6 African green monkey kidney cells, and human hepatoma cells for cell-based studies. The nasal epithelial cells were obtained through air-liquid interface cultures of nasal epithelial progenitor cells. These cells were procured from healthy humans undergoing plastic surgery of the septa.
The CADD compounds and the compounds in the natural product library were screened for efficacy in pre-infection treatment, while the flavonoids and the FDA-approved drugs were screened for post-infection treatment efficacy. Cell viability at four days after infection based on virus-induced cytopathic effects or toxicity to the compound was used to assess the primary screening results.
Keratin 18-human angiotensin converting enzyme-2 mouse models were used for the in vivo tests involving treatment with different concentrations of calcitriol and subsequent intranasal infection with SARS-CoV-2. Viral titer assessments and histological analyses were conducted four days after infection.
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