Get a COVID-19 booster shot now or wait? Many wonder how best to ride out the pandemic's next wave

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Get a COVID-19 booster shot now or wait? Many wonder how best to ride out the pandemic's next wave
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About 70% of people 50 and older who got a first COVID-19 booster shot haven't received the recommended second one, according to the CDC.

Consistent messaging has been complicated by the different views of leading vaccine scientists. Although physicians like del Rio and Dr. Peter Hotez of Baylor College of Medicine see the value in getting a second booster, Dr. Paul Offit, a member of the FDA's vaccine advisory committee, is skeptical it's needed by anyone but seniors and people who are immunocompromised.

During the first White House COVID briefing in nearly three weeks, the message from top federal health officials was clear: Don't wait for an Omicron-tailored shot."There are many people who are at high risk right now, and waiting until October, November for their boost — when in fact their risk is in the moment — is not a good plan," said Dr. Rochelle Walensky, head of the CDC.

The FDA on July 13 authorized a fourth COVID vaccine, made by Novavax, but only for people who haven't been vaccinated yet. Many scientists thought the Novavax shot could be an effective booster for people previously vaccinated with mRNA shots from Pfizer-BioNTech and Moderna because its unique design could broaden the immune response to coronaviruses. Unfortunately, few studies have assessed mix-and-match vaccination approaches, said Gellin, of the Rockefeller Foundation.

The Omicron vaccines will contain components that target the original strain of the virus because the first vaccine formulations are known to prevent serious illness and death even in people infected with Omicron.

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