A study published in the journal Protein & Cell details the connection between SCARB2 deficiency and gastrointestinal dysfunction, revealing that the loss of SCARB2 leads to alterations in bile acid metabolism and dysbiosis in the gut microbiome.
Gut dysbiosis found to impair intestinal renewal and lipid absorption in Scarb2 deficiency-associated neurodegeneration retrieved 23 August 2024 from https://medicalxpress.com/news/2024-08-gut-dysbiosis-impair-intestinal-renewal.html
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SCARB2 deficiency disrupts bile acid metabolism and gut microbiomeThe study details the connection between SCARB2 deficiency and gastrointestinal dysfunction, revealing that the loss of SCARB2 leads to alterations in bile acid metabolism and dysbiosis in the gut microbiome. This disruption affects the signaling pathway involving FXR, which normally regulates bile acid synthesis and intestinal lipid absorption.
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