Scientists at Open Targets, the European Molecular Biology Laboratory’s European Bioinformatics Institute (EMBL-EBI), and GSK are revealing the shared basis of diseases using a map of interacting human proteins. By helping to understand how biological processes affect human traits and diseases, this
. Using this interactome, they identified groups of proteins interacting with genes that have been linked through GWAS to over 1,000 human traits from 21 therapeutic areas.Proteins that interact with each other will likely be involved in the same biological processes. Therefore, if a protein is known to be involved in a disease, knowing which partners it interacts with provides information about the function it has in a cell.
“The interactome identified some known associations, such as cardiovascular diseases and lipoprotein or cholesterol measurements,” said Inigo Barrio Hernandez, postdoctoral fellow at Open Targets and EMBL-EBI. “But we also found some unexpected associations. For example, the interactome highlighted three protein clusters shared by ten respiratory and skin immune-related diseases.
“This work bridges many fields of biology, including statistical genetics, cell biology, and bioinformatics,” said Pedro Beltrao, Associate Professor at ETH Zurich and former Group Leader at EMBL-EBI. “It brought together groups from across Open Targets and EMBL-EBI, and highlights the value of collaborations across disciplines.”
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