Northwestern Medicine investigators have identified how a calcium channel in the nervous system contributes to brain inflammation, according to a study published in Nature Communications.
. Because astrocyte activity is regulated by intracellular calcium, investigators first bred mice without the ORAI1 gene, which has been shown to control calcium signaling in many mammalian cells including immune cells and microglia.
Importantly, the ORAI1 astrocyte knockout mice were protected against inflammation-related behavioral depression, according to the study.
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