A groundbreaking study involving over five million people from diverse backgrounds has identified nearly 300 previously unknown genetic links to depression. This unprecedented research, published in the journal Cell, highlights the importance of inclusivity in genetic studies and suggests potential for more effective therapies tailored to different ethnicities.
New research has revealed nearly 300 previously unknown genetic links to depression, in the world’s largest and most diverse genetic study into the condition ever.
The authors say the findings, published in the journal Cell, will allow scientists to predict risk of major depression regardless of ethnicity and may help to develop more effective therapies for the condition. The research team looked at anonymised genetic data from more than five million people in 29 countries across the globe. One in four individuals included in the study were from non-European descent.
The findings offer new insight into depression’s effect on the brain and offer possible new targets for treatment, experts say. The team highlighted that existing drugs pregabalin and modafinil – currently used to treat chronic pain and the narcolepsy, respectively – could potentially be repurposed for the treatment of depression, based on the study findings.
GENETICS DEPRESSION HEALTHINEQUALITIES THERAPIES RESEARCH
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