If you've ever had a rough night's sleep and felt like your brain was running on empty the next day, you might not be surprised to hear it's more than a fleeting feeling.
"We found that PTN is associated with sleep-loss-induced cognitive impairment," the team from Binzhou Medical University in China"Our work suggests that PTN mediated signaling is a novel mechanism by which sleep protects cognitive function."
Scientists have begun looking into variations in protein and RNA levels to learn more about the underlying changes that are producing the effect ofTo assess the impact of insomnia on the cognitive abilities of mice, the researchers tested the animals' spatial skills when navigating a maze and their short-term memory when recognizing a novel object.
Since the tests themselves could potentially influence the hippocampal proteins, the researchers carefully timed their assessments, conducting analysis 24 hours after the maze test. Protein analysis showed 164 proteins were expressed differently in the brains of the insomnia model mice compared to control mice.
Many of those proteins are associated with pathways in the hippocampus that have been related to neurodegenerative diseases including Alzheimer's,
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