A groundbreaking paper in Nature describes a promising new therapy for obesity that leads to greater weight loss in mice than existing medications.
May 16 2024University of Copenhagen - The Faculty of Health and Medical Sciences The approach smuggles molecules into the brain's appetite center and affects the brain's neuroplasticity.
The effect of GLP-1 combined with these molecules is very strong. In some cases, the mice lose twice as much weight as mice treated with GLP-1 only." Testing of the new weight loss drug is still in the so-called preclinical phase, which is based on studies with cells and on experimental animals. The next step is clinical trials with human participants.
Related StoriesThe molecules block a receptor protein called the NMDA receptor, which play a key role in long-term changes in brain connections and have received scientific attention within fields of learning and memory. Drugs targeting these receptors will strengthen and/or weaken specific nerve connections.
Weight Loss Brain Drugs Food GLP-1 Hormone Molecule Nausea Neurons Obesity Receptor Research Small Molecules Therapeutics
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