A new Northwestern Medicine study challenges a common belief in what triggers Parkinson's disease.
Northwestern scientists found that dopaminergic synapses are not functioning correctly in various genetic forms of Parkinson's disease. This work, together with other recent studies by Krainc's lab, addresses one of the major gaps in the field: how different genes linked to Parkinson's lead to degeneration of human dopaminergic neurons.Imagine two workers in a neuronal recycling plant.
It has been well-established that people who carry mutations in both copies of either PINK1 or Parkin develop Parkinson's disease because of ineffective mitophagy.had the misfortune of being born without the PINK1 gene, because their parents were each missing a copy of the critical gene. This put the sisters at high risk for Parkinson's disease, but one sister was diagnosed at age 16, while the other was not diagnosed until she was 48.
"There must be a complete loss of Parkin to cause Parkinson's disease. So, why did the sister with only a partial loss of Parkin get the disease more than 30 years earlier?" Krainc asked.
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