Novel triple assortments of swine influenza virus detected in pigs by active surveillance analysis in China SSRN virus influenza swineflu flu virology
By Pooja Toshniwal PahariaMar 10 2023Reviewed by Benedette Cuffari, M.Sc. *Important notice: Preprints with The Lancet publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.
Background Omics eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Swine is essentially involved in the influenza virus evolution, with prevalent swine influenza virus subtypes including H1N1, H1N2, and H3N2. H1N1 swine influenza viruses include the classical swine -type H1N1, Eurasian avian -type H1N1, and 2009 pandemic H1N1, which is often referred to as 2009/H1N1.
Cells of the swine upper respiratory epithelium secrete α-2,3-linked sialic acid avian-like receptors and α-2,6-linked sialic acid human-like receptors. As a result, influenza viruses that are avian and mammalian in their origin can successfully infect swine, thus allowing these animals to act as ‘mixing vessels’ for different influenza viruses.
To further explore the genomic constitution of the H1N2 swine influenza viruses, all swine sequences were downloaded and divided into 12 genotypes ranging from G1 to G12. Molecular marker analysis was performed and the origination of HA genes was determined. The three H1N2 swine influenza viruses detected in the Liaoning province gained their HA genes from the human 2009 pandemic H1N1 viruses circulating in 2019 that were transmitted to pigs from humans.
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