China announced on Friday an easing of its strict Covid measures that have weighed on the oil market in recent months, sending oil prices higher by more than 2.5% in early trade in Europe.
UN Launches Satellite System To Track Methane EmissionsHigh Oil Prices Ignite The Middle Eastern IPO MarketOil Executives Warn G7 Price Cap Could Lead To Stranded TankersWorld’s Top Chipmaker Eyes Arizona For New $12 Billion Semiconductor PlantWatchdogs Say Iran Boosting Stockpiles Of Atomic FuelsBitcoin Facing An Existential Crisis As Exchange Meltdown ContinuesTraders Use Iron Ore Carriers To Transport Coal As Energy Demand RisesThe EU's Energy Partnership With Gulf Countries Makes “More...
8 Billion On Australia’s Energy TransitionUK’s Market-Defying North Sea Oil IPO Falls FlatZelenskiy Calls For Extension Of Black Sea Grain Export DealRussian Black Sea Fleet Headquarters Hit With “Unprecedented” Drone Attack'Security Advisor: Maintaining Contact With Kremlin ‘In The Interests’ Of U.S.
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Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19: The Global COVID-19 Stroke RegistryBackground and objectives: COVID-19 related inflammation, endothelial dysfunction and coagulopathy may increase the bleeding risk and lower efficacy of revascularization treatments in patients with acute ischemic stroke. We aimed to evaluate the safety and outcomes of revascularization treatments in patients with acute ischemic stroke and COVID-19. Methods: Retrospective multicenter cohort study of consecutive patients with acute ischemic stroke receiving intravenous thrombolysis (IVT) and/or endovascular treatment (EVT) between March 2020 and June 2021, tested for SARS-CoV-2 infection. With a doubly-robust model combining propensity score weighting and multivariate regression, we studied the association of COVID-19 with intracranial bleeding complications and clinical outcomes. Subgroup analyses were performed according to treatment groups (IVT-only and EVT). Results: Of a total of 15128 included patients from 105 centers, 853 (5.6%) were diagnosed with COVID-19. 5848 (38.7%) patients received IVT-only, and 9280 (61.3%) EVT (with or without IVT). Patients with COVID-19 had a higher rate of symptomatic intracerebral hemorrhage (SICH) (adjusted odds ratio [OR] 1.53; 95% CI 1.16–2.01), symptomatic subarachnoid hemorrhage (SSAH) (OR 1.80; 95% CI 1.20–2.69), SICH and/or SSAH combined (OR 1.56; 95% CI 1.23–1.99), 24-hour (OR 2.47; 95% CI 1.58–3.86) and 3-month mortality (OR 1.88; 95% CI 1.52–2.33). COVID-19 patients also had an unfavorable shift in the distribution of the modified Rankin score at 3 months (OR 1.42; 95% CI 1.26–1.60). Discussion: Patients with acute ischemic stroke and COVID-19 showed higher rates of intracranial bleeding complications and worse clinical outcomes after revascularization treatments than contemporaneous non-COVID-19 treated patients. Current available data does not allow direct conclusions to be drawn on the effectiveness of revascularization treatments in COVID-19 patients, or to establish different treatment recommendations in this subgro
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Frontiers | Oropharyngeal microbiome profiled at admission is predictive of the need for respiratory support among COVID-19 patientsThe oropharyngeal microbiome, the collective genomes of the community of microorganisms that colonizes the upper respiratory tract, is thought to influence the clinical course of infection by respiratory viruses, including Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus Infectious Disease 2019 (COVID-19). In this study, we examined the oropharyngeal microbiome of suspected COVID-19 patients presenting to the Emergency Department and an inpatient COVID-19 unit with symptoms of acute COVID-19. Of 115 initially enrolled patients, 50 had positive molecular testing for COVID-19+ and had symptom duration of 14 days or less. These patients were analyzed further as progression of disease could most likely be attributed to acute COVID-19 and less likely a secondary process. Of these, 38 (76%) went on to require some form of supplemental oxygen support. To identify functional patterns associated with respiratory illness requiring respiratory support, we applied an interpretable random forest classification machine learning pipeline to shotgun metagenomic sequencing data and select clinical co-variates. When combined with clinical factors, both species and metabolic pathways abundance-based models were found to be highly predictive of the need for respiratory support (F1-score 0.857 for microbes and 0.821 for functional pathways). To determine biologically meaningful and highly predictive signals in the microbiome, we applied the Stable and Interpretable RUle Set (SIRUS) to the output of the models. This analysis revealed that low abundance of two commensal organisms, Prevotella salivae or Veillonella infantium (less than 4.2% and 1.7% respectively), and a low abundance of a pathway associated with LPS biosynthesis (less than 0.1%) were highly predictive of developing the need for acute respiratory support (82% and 91.4% respectively). These findings suggest that the composition of the oropharyngeal microbiome in COVID-19 patien
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Financial markets bet on an end to China’s “zero-covid” policyThere are some signs change may be on the way
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Melatonin could be a potential therapy for long-COVID symptomsA recent review published in the journal Biomolecules discussed the potential uses of melatonin in treating brain fog, and chronic fatigue syndrome or myalgic encephalomyelitis symptoms associated with long coronavirus disease (COVID)
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Doctors move to reassure patients after vaccinators accidentally use half doses of Covid boostersA medical centre near Oswestry has apologised to patients after discovering that vaccinators have inadvertently been giving patients half the recommended dose of Covid boosters.
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