Russia's plan to roll-out its 'Sputnik-V' COVID-19 vaccine even before full trials show how well it works is prompting concern among virus experts, who warn a partially effective shot may encourage the novel coronavirus to mutate.
LONDON - Russia’s plan to roll-out its “Sputnik-V” COVID-19 vaccine even before full trials show how well it works is prompting concern among virus experts, who warn a partially effective shot may encourage the novel coronavirus to mutate.
But some scientists are worried that adding “evolutionary pressure” to the pathogen by deploying what might not be a fully protective vaccine could make things worse. Russia said on Thursday it plans to begin a large-scale efficacy trial of the vaccine in a total of 40,000 people, but will also begin administering it to people in high-risk groups, such as healthcare workers, before the trial has produced any results.
Dan Barouch, a specialist at Harvard’s Beth Israel Deaconess Medical Center in Boston, noted that mutation rates for coronaviruses are far lower than for viruses like HIV, but added: “There are many potential downsides of using a vaccine that doesn’t work. The risk that it would mutate is a theoretical risk.”
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