The study uncovers factors influencing mpox severity and duration, emphasizing the role of viral load and specific clinical presentations in patient outcomes.
By Dr. Priyom Bose, Ph.D.Reviewed by Lily Ramsey, LLMSep 2 2024 A recent study published in eBioMedicine explored the clinical and laboratory predictors of mpox severity and duration. It also tested the correlation between viral load and disease severity in biological fluids.
The clinical severity and outcome of human mpox could be determined by several factors, such as prior vaccination or infection, viral clade, promptness of medical care, baseline health condition, and so on. To characterize the kinetics of inflammatory markers and to understand virus detection in different compartments of the body post-clinical resolution, the risk factors associated with enhanced MPXV virulence were also studied.
Study findings The sample comprised 541 patients, of which only four were women. The median age was 38 years and about 43% were people living with HIV . This was done by assessing MPXV DNA in the upper respiratory tract in the first week of the disease. Accounting for heterogeneity across clinical centers, the likelihood of severe disease was noted to be inversely proportional to the Ct-value.
CD4 CT DNA Fever HIV Laboratory Lymphadenopathy Proctitis Rash Respiratory Sore Throat Throat Virus
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