A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as 'Aging (Albany NY)' and 'Aging-US' by Web of Science) Volume 16, Issue 8, entitled, 'Senescent characteristics of human corneal endothelial cells upon ultraviolet-A exposure.
Apr 30 2024 Aging -US A new research paper was published on the cover of Aging " and " Aging -US" by Web of Science) Volume 16, Issue 8, entitled, "Senescent characteristics of human corneal endothelial cells upon ultraviolet-A exposure."
In this new study, researchers Kohsaku Numa, Sandip Kumar Patel, Zhixin A. Zhang, Jordan B. Burton, Akifumi Matsumoto, Jun-Wei B. Hughes, Chie Sotozono, Birgit Schilling, Pierre-Yves Desprez, Judith Campisi , and Koji Kitazawa from Buck Institute for Research on Aging, Kyoto Prefectural University of Medicine, University of Cambridge, and California Pacific Medical Center investigated the senescent phenotypes of human corneal endothelial cells upon treatment with ultraviolet -A.
"We assessed cell morphology, senescence-associated β-galactosidase activity, cell proliferation and expression of senescence markers in hCEnCs exposed to UV-A radiation, and senescent hCEnCs induced by ionizing radiation were used as positive controls." The researchers performed RNA sequencing and proteomics analyses to compare gene and protein expression profiles between UV-A- and IR-induced senescent hCEnCs -; they also compared the results to non-senescent hCEnCs. Cells exposed to 5 J/cm2 of UV-A or to IR exhibited typical senescent phenotypes, including enlargement, increased SA-β-gal activity, decreased cell proliferation and elevated expression of p16 and p21. RNA-Seq analysis revealed that 83.
"In this study, where senescence was induced by UV-A, a more physiological stress for hCEnCs compared to IR, we determined that UV-A modulated the expression of many genes and proteins typically altered upon IR treatment, a more conventional method of senescence induction, even though UV-A also modulated specific pathways unrelated to IR."Journal reference:Numa, K., et al. . Senescent characteristics of human corneal endothelial cells upon ultraviolet-A exposure. Aging. doi.org/10.
Cancer Cell Cell Biology Cell Proliferation Gene Genes Medicine Phenotype Proliferation Proteomics Research RNA
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