Substance P neuropeptides' role in post-COVID-19 conditions revealed in recent study Tachykinins Neuroimmune PostCOVID SubstanceP neuropeptide LancetMicrobe
By Dr. Priyom Bose, Ph.D.Jun 15 2023Reviewed by Benedette Cuffari, M.Sc. The rapid spread of the severe acute respiratory syndrome coronavirus-2 led to the coronavirus disease 2019 pandemic. Common post-COVID-19 symptoms include fatigue, muscle weakness, headaches, pulmonary dysfunction, anxiety, digestive disorders, anosmia, sexual dysfunction, difficulty concentrating, and dysgeusia.
Tachykinins and physiopathological processes Tachykinins defend the host against harmful stressors, during which the nervous system rapidly communicates with immune cells so that it can quickly respond to pathogenic invasion. Related StoriesTachykinins are associated with processes such as pain, acute inflammation, infection, cancer, venous thromboembolism, hematopoiesis, and taste perception. Substance P and its receptor NK1R are present in the brain region that regulates vomiting urges, with antagonism against this receptor used to treat chemotherapy-induced nausea and vomiting.
NK1R antagonist disrupts NK1R and substance P signaling, thereby reversing pulmonary inflammation and injury. These studies indicate the likely role of substance P in pulmonary dysfunction linked to post-COVID-19 conditions and the therapeutic potential of NK1R antagonism to block this pathology.
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