The prognostic value of PCSK9 levels for predicting major adverse cardiovascular events and mortality in diabetics researchsquare unimib cardiovascular diabetes health disease
By Susha Cheriyedath, M.Sc.Jul 17 2023Reviewed by Benedette Cuffari, M.Sc. Globally, atherosclerotic cardiovascular disease is the primary cause of illness and death and is much more common in with type 2 diabetes mellitus patients than non-diabetic individuals. Nevertheless, for approximately ten years, the identification of distinct prognostic risk biomarkers remains challenging.
About the study A total of 529 T2DM patients were included in the current study with a median age of 67 years. The diagnosis of T2DM was based on criteria established by the American Diabetes Association , which includes glycated hemoglobin levels, fasting and two-hour blood glucose levels, and diabetes symptoms. Patients between 40 and 87 years of age who had a body mass index of less than 40 kg/m2 were eligible for the study.
Study findings At enrollment, 289 patients had at least one T2DM complication. Among the 240 patients without complications, 149 subsequently developed complications. Sex-specific cutoffs of 244 ng/mL for males and 299 ng/mL for females were determined to maximize survival prediction differences. Above these cutoffs, 31.3% and 51.8% of females and males, respectively, had elevated PCSK9 levels.
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