Unraveling the consequences: COVID-19's devastating effect on the TB care cascade medrxivpreprint StellenboschUni covid COVID19 SARSCoV2 TB tuberculosis healthequity LMICs
By Hugo Francisco de SouzaJul 17 2023Reviewed by Lily Ramsey, LLM In a recent pre-print posted to the medRxiv* server, researchers conducted a systematic review to evaluate the impact of coronavirus disease 2019 on the tuberculosis care cascade. They screened 27 studies across North America, South America, Asia, Africa, and Europe.
Tuberculosis during the pandemic Tuberculosis is one of the most ubiquitous and deadly diseases globally, responsible for an estimated 1.8 billion asymptomatic carriers, 10.6 million symptomatic patients, and 1.5 million casualties in 2018. In LMICs, COVID-19 is thought to have impacted entire health systems, severely impacting care cascades in diseases such as TB and AIDS, which require constant contact between patients and medical professionals at all infection stages.
Repercussions of COVID-19 on TB care – a review In the present pre-print, researchers conducted a systematic review to quantify the impacts of the pandemic on delaying or even reversing the global effort toward the End TB strategy. Two researchers then independently extracted data about changes in the number of patients processed through the TB care cascade and included characterization of the loss to follow-up, potential patients not evaluated, and TB-related or suspected deaths during the pandemic.
This study found that clinical TB diagnoses decreased by up to 46% and case notifications by more than 63% during the pandemic. The pandemic caused treatment delays of more than five days, which, when clubbed with reduced treatment success rates , might have had severe repercussions on TB-related morbidity and mortality.
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