Weyes Blood is searching for a way through the dark times 🟠 Katiesol writes on Weyes Blood's latest offering.
’s fifth album sounds a bit like the end of the world. Every song is woven of layer upon layer of music that has more than a little of the wrath of the heavens about it, rich pealing chorals and strings that dissolve into synths. Each track is like a mini epic, brimming over as she sings in a way that feels desperate and repentant.
The Californian, whose real name is Natalie Mering, seems concerned with the tiny light glowing in the dark: the songs on this album all seem busy and chaotic but there is always a moment of clarity to them, even if that is at the very end – like on “Hearts Aglow”, which flutters into a harp strum after six minutes of searching for hope in a crumbling world.
There’s something monstrous about the sheer wall of sound Weyes Blood has built on this record: the feeling of being closed in on by the music, which echoes the feeling of being bombarded by bad news at every turn .
Deutschland Neuesten Nachrichten, Deutschland Schlagzeilen
Similar News:Sie können auch ähnliche Nachrichten wie diese lesen, die wir aus anderen Nachrichtenquellen gesammelt haben.
Frontiers | Increased IL-26 associates with markers of hyperinflammation and tissue damage in patients with acute COVID-19Interleukin-26 (IL-26) is released by several immune and structural cells following stimulation of toll-like receptors (TLRs), whereupon it can directly inhibit viral replication and enhance neutrophil chemotaxis. Given these unique properties, IL-26 has emerged as an intriguing mediator of host defense in the lungs. However, the role of IL-26 in COVID-19 has not been thoroughly investigated. Here, we characterized the involvement of IL-26 in the hyperinflammation and tissue damage that occurs in patients with acute COVID-19. We found that IL-26 is markedly increased in blood samples from these patients, and that the concentration of IL-26 correlates with those of the neutrophil-mobilizing cytokines IL-6, IL-8, and TNFα, respectively. Moreover, the increase in blood IL-26 correlates with enhanced surface expression of the “don’t eat me” signal CD47 on blood neutrophils isolated from patients with acute COVID-19. Finally, we found that the blood concentration of IL-26 correlates with that of increased lactate dehydrogenase, an established marker of tissue damage, and decreased mean corpuscular hemoglobin (MCH), a previously verified hematological aberration in COVID-19, both of which are associated with severe disease. Thus, our findings indicate that increased systemic IL-26 associates with markers of hyperinflammation and tissue damage in patients with acute COVID-19, thereby forwarding the kinocidin IL-26 as a potential target for diagnosis, monitoring, and therapy in this deadly disease.
Weiterlesen »
Theranos scandal: Who is Elizabeth Holmes and why was she on trial?The former boss of blood testing company Theranos was found guilty of fraud in January and will be sentenced on Friday.
Weiterlesen »
Men took bottles and a curtain pole into Leeds restaurant after fight 'erupted'Two men that entered a Leeds restaurant after a fight erupted carrying a curtain pole and a broken bottle and then left covered in blood have been sentenced.
Weiterlesen »
Imaging of C-X-C Motif Chemokine Receptor 4 Expression in 690 Patients with Solid or Hematologic Neoplasms Using 68Ga-Pentixafor PETIn recent years, molecular imaging addressing the C-X-C motif chemokine receptor 4 (CXCR4) has increasingly been used in various clinical settings. Here, we aimed to assess radiopharmaceutical uptake and image contrast to determine the most relevant clinical applications for CXCR4-directed imaging. We also investigated the impact of specific activity on scan contrast. Methods: Patients ( n=690) with a variety of neoplasms underwent a total of 777 PET/CT scans with 68Ga-Pentixafor, serving as the CXCR4-specific radioligand. A semiquantitative target lesion analysis was conducted (providing SUVmax and target-to-blood pool ratio [TBR], defined as SUVmax [from target lesion] divided by SUVmean [from blood pool]). The applied specific activity (in MBq/μg) was compared with semiquantitative assessments. Results: Of the 777 scans, 242 did not show discernible uptake in disease sites, leaving 535 PET scans (68.9%) for further analysis. Very high tracer uptake (SUVmax | 12) was found in multiple myeloma ( n=113), followed by adrenocortical carcinoma ( n=30), mantle cell lymphoma ( n=20), adrenocortical adenoma ( n=6), and small cell lung cancer ( n=12). Providing information on image contrast, comparable results for TBR were recorded, with TBR (|8) in multiple myeloma, mantle cell lymphoma, and acute lymphoblastoid leukemia ( n=6). When comparing specific activity with semiquantitative parameters, no significant correlation was found for SUVmax or TBR ( P ≥ 0.612). Conclusion: In this large cohort, 68Ga-Pentixafor demonstrated high image contrast in a variety of neoplasms, particularly for hematologic malignancies, small cell lung cancer, and adrenocortical neoplasms. The present analysis may provide a roadmap for detecting patients who may benefit from CXCR4-targeted therapies.
Weiterlesen »
IgG response to spike protein of SARS-CoV-2 in healthy individuals and potential of intravenous IgG as treatment for COVID-19 - Virology JournalBackground The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19), which is currently a worldwide pandemic. There are limited available treatments for severe COVID-19 patients. However, some evidence suggests that intravenous immunoglobulin (IVIg) provides clinical benefits for these patients. Methods We administered IVIg to 23 severe COVID-19 patients, and all of them survived. Four related coronaviruses can cause the common cold. We speculated that cross-reactivity of SARS-CoV-2 and other common coronaviruses might partially explain the clinical efficacy of IVIg therapy. Thus, we performed multiple alignment analysis of the spike (S), membrane (M), and nucleotide (N) proteins from SARS-CoV-2 and the common coronaviruses to identify conserved regions. Next, we synthesized 25 peptides that were conserved regions and tested their IVIg seropositivity. Results The results indicated four peptides had significant or nearly significant seropositivity, and all of them were associated with the S and M proteins. Examination of the immune responses of healthy volunteers to each synthetic peptide indicated high seropositivity to the two peptides from S protein. Blood samples from healthy individuals may have pre-existing anti-SARS-CoV-2 IgGs, and IVIg is a potentially effective therapy for severe COVID-19. Conclusion In conclusion, blood samples from many healthy individuals have pre-existing anti-SARS-CoV-2 IgGs, and IVIg may be an effective therapy for severe COVID-19.
Weiterlesen »