A study published in Gut Pathogens finds that in Indian patients with COVID-19, a dysbiotic gut microbial community may play an important role in disease severity. Modulation of gut microbiota through diet interventions may reduce disease severity.
]. Decarboxylation of histidine to histamine by gut microbes hasalready been reported. This amino acid has potent immunomodulatory effects through activation of histamine receptors and the authors have stated thatProgression of SARS-CoV-2 infection to advanced stages is usuallyaccompanied by a vicious inflammatory response that in the future often leads to multiorgan failure.
Our study has a few limitations, including a relatively small sample size with mild disease, a lack of asymptomatic patients, and a non-COVID control group from the same hospital at the same time, which may have overlooked potential confounding factors. Although a large cohort size would have been desirable to firmly establish a relationship between COVID-19 severity and gut dysbiosis, the taxonomic dysbiosis identified in the present study is significant.
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